VAriation effect on
PROtein Structure and function TABLE
VaProS Table
UniProt accession(e.g.,P11499)
UniProt ID(e.g.,HS90B_MOUSE)
Protein name
Sequence length
Number of PDB entries corresponding to the UniProt entry
Experimental method for structure determination
Fraction of amino acid residues covered by corresponding PDB entries (union)
Fraction of amino acid residues covered by the closest corresponding PDB homolog
Fraction of amino acid residues covered by corresponding PDB entries excluding disordered regions (union)
Number of mutants annonated in the PDB, including (1) those annotated as "MUTATION" in SEQADV, and (2) MODRES (modified residue)
Number of PDB homologs detected by BLAST
Fraction of residues covered by PDB homologs (union).
Weighted average of sequence identity.
Fraction of residues covered by PDB homologs (union) excluding disordered regions.
Fraction of residues covered by the closest PDB homolog.
Sequence identity of the closest PDB homolog.
Number of (contiguous) disordered regions.
Fraction of residues in disoredered regions.
Fraction of residues in predicted alpha helices.
Fraction of residues in predictied beta strands.
Number of unique domains (i.e., repeated domains are counted once).
Number of domains(i.e., repeated domains are multiply counted).
Pfam domain identifier(s).
Pfam domain name(s).
Whether a ligand is bound or not.
Number of chemical compounds found in PDB homologs.
Number of metals found in PDB homologs.
Number of nucleotides found in PDB homologs.
Number of "other" polymers found in PDB homologs.
Number of (supposed) precipitants found in PDB homologs.
Ligand names foundin PDB homologs.
Number of monomeric structures in PDB homologs.
Number of homomeric structures in PDB homologs.
Number of heteromeric structures in PDB homologs.
Number of other protein complex structures in PDB homologs.
Number of homologs in the "HUM" (human) division.
Number of homologs in the "PRI" (primates) division.
Number of homologs in the "ROD" (rodents) division.
Number of homologs in the "MAM" (mammals) division.
Number of homologs in the "VRT" (vertebrates) division.
Number of homologs in the "INV" (invertebrates) division.
Number of homologs in the "PLN" (plants) division.
Number of homologs in the "BCT" (bacteria) division.
Number of homologs in the "ARC" (archeae) division.
Number of potential ligands (chemical compounds).
Number of splice variants (isoforms).
Number of variant sites.
Number of sequence variants.
Subcellular location
List of related diseases.
Number of related PubMed entries.
length
Bin▲
Count
Percentage
10~248
39440
61.30%
249~487
12545
19.50%
488~726
5822
9.05%
727~965
2778
4.32%
966~1206
1492
2.32%
1207~1461
866
1.35%
1462~1743
487
0.76%
1744~2108
370
0.58%
2114~2812
292
0.45%
2818~34349
248
0.39%
num_pdb_entries
Bin▲
Count
Percentage
0
59130
91.90%
1~10
4679
7.27%
11~20
296
0.46%
21~30
89
0.14%
31~40
54
0.08%
41~52
26
0.04%
53~69
22
0.03%
75~90
13
0.02%
92~121
12
0.02%
122~201
11
0.02%
204~469
8
0.01%
coverage_pdb_union
Bin▲
Count
Percentage
0
59132
91.91%
0.3~10
528
0.82%
10.1~19.8
541
0.84%
19.9~29.6
459
0.71%
29.7~39.5
377
0.59%
39.6~49.7
322
0.50%
49.8~60.6
334
0.52%
60.7~70.9
320
0.50%
71~80.8
374
0.58%
80.9~90.7
419
0.65%
90.8~100
1534
2.38%
coverage_pdb_top
Bin▲
Count
Percentage
0
59903
93.10%
0.3~10.8
410
0.64%
10.9~20.5
506
0.79%
20.6~30.2
411
0.64%
30.3~40.1
334
0.52%
40.2~50.3
295
0.46%
50.4~60.8
294
0.46%
60.9~71
302
0.47%
71.1~80.9
353
0.55%
81~90.7
405
0.63%
90.8~100
1127
1.75%
coverage_pdb_union_wo_diso
Bin▲
Count
Percentage
0
59179
91.98%
0.2~10.2
404
0.63%
10.3~20
426
0.66%
20.1~29.9
388
0.60%
30~40
365
0.57%
40.1~49.8
342
0.53%
49.9~60.4
323
0.50%
60.5~71
310
0.48%
71.1~80.8
348
0.54%
80.9~90.8
456
0.71%
90.9~100
1799
2.80%
pdb_mutant
Bin▲
Count
Percentage
0
62281
96.80%
1~6
1803
2.80%
7~12
143
0.22%
13~18
44
0.07%
19~24
19
0.03%
25~31
17
0.03%
33~39
9
0.01%
40~47
10
0.02%
48~59
6
0.01%
61~96
7
0.01%
276
1
0.00%
num_pdb_homolog
Bin▲
Count
Percentage
0
21191
32.94%
1~220
36358
56.51%
221~440
2777
4.32%
441~660
1499
2.33%
661~909
839
1.30%
910~1268
346
0.54%
1273~1679
353
0.55%
1680~2291
266
0.41%
2296~3041
258
0.40%
3045~4412
235
0.37%
4415~45567
218
0.34%
coverage_homolog_union
Bin▲
Count
Percentage
0
21191
32.94%
1.1~11.1
740
1.15%
11.2~21.1
1686
2.62%
21.2~31.1
2466
3.83%
31.2~41.1
2818
4.38%
41.2~51.1
3230
5.02%
51.2~61.1
3467
5.39%
61.2~71.1
3903
6.07%
71.2~81.1
4871
7.57%
81.2~91.1
6051
9.40%
91.2~100
13917
21.63%
identity_homolog_union
Bin▲
Count
Percentage
0
21192
32.94%
2.9~38.4
157
0.24%
38.5~45.3
672
1.04%
45.4~52.2
2954
4.59%
52.3~59.1
9800
15.23%
59.2~66
12195
18.95%
66.1~72.9
8227
12.79%
73~79.8
3978
6.18%
79.9~86.7
2126
3.30%
86.8~93.6
1291
2.01%
93.7~100
1748
2.72%
coverage_homolog_union_coverage
Bin▲
Count
Percentage
0
21272
33.06%
0.2~11.3
531
0.83%
11.4~21.2
1148
1.78%
21.3~31.1
1573
2.44%
31.2~41
2131
3.31%
41.1~50.9
2536
3.94%
51~60.8
2846
4.42%
60.9~70.7
3273
5.09%
70.8~80.6
4292
6.67%
80.7~90.5
5885
9.15%
90.6~100
18853
29.30%
coverage_homolog_top
Bin▲
Count
Percentage
0
21214
32.97%
1.1~11.1
950
1.48%
11.2~21.1
2238
3.48%
21.2~31.1
3062
4.76%
31.2~41.1
3487
5.42%
41.2~51.1
3905
6.07%
51.2~61.1
4286
6.66%
61.2~71.1
4763
7.40%
71.2~81.1
5678
8.82%
81.2~91.1
6108
9.49%
91.2~100
8649
13.44%
identity_homolog_top
Bin▲
Count
Percentage
0
21215
32.97%
7.4~37
190
0.30%
37.1~44.3
656
1.02%
44.4~51.4
1752
2.72%
51.5~58.5
4265
6.63%
58.6~65.6
6403
9.95%
65.7~72.7
5632
8.75%
72.8~79.8
4233
6.58%
79.9~86.9
3302
5.13%
87~94
3692
5.74%
94.1~100
13000
20.21%
num_id_region
Bin▲
Count
Percentage
0
5057
7.86%
1~8
55893
86.87%
9~16
2482
3.86%
17~24
546
0.85%
25~32
183
0.28%
33~40
86
0.13%
41~48
37
0.06%
49~57
21
0.03%
58~66
20
0.03%
69~89
9
0.01%
90~215
6
0.01%
frac_id_region
Bin▲
Count
Percentage
0
5058
7.86%
0.1~10
24910
38.72%
10.1~20
12568
19.53%
20.1~30
7671
11.92%
30.1~40
5047
7.84%
40.1~50
3292
5.12%
50.1~60
1997
3.10%
60.1~70
1435
2.23%
70.1~80
916
1.42%
80.1~90.1
616
0.96%
90.2~99.9
830
1.29%
frac_alpha
Bin▲
Count
Percentage
0
25942
40.32%
0.1~9.1
6883
10.70%
9.2~18.2
7632
11.86%
18.3~27.3
7902
12.28%
27.4~36.4
6614
10.28%
36.5~45.5
4158
6.46%
45.6~54.6
2318
3.60%
54.7~63.7
1542
2.40%
63.8~72.8
880
1.37%
72.9~82.7
349
0.54%
82.8~100
120
0.19%
frac_beta
Bin▲
Count
Percentage
0
30576
47.52%
0.1~6.3
6834
10.62%
6.4~12.6
7563
11.75%
12.7~18.9
6992
10.87%
19~25.2
5138
7.99%
25.3~31.5
2961
4.60%
31.6~37.8
1723
2.68%
37.9~44.1
1296
2.01%
44.2~50.4
802
1.25%
50.5~56.8
349
0.54%
57~71.9
106
0.16%
num_domain_variety
Bin▲
Count
Percentage
0
17310
26.90%
1~4
40835
63.47%
5~8
4819
7.49%
9~12
1091
1.70%
13~16
220
0.34%
17~20
39
0.06%
21~24
15
0.02%
25~28
7
0.01%
29~37
4
0.01%
num_domains
Bin▲
Count
Percentage
0
17310
26.90%
1~22
44879
69.75%
23~44
1103
1.71%
45~66
422
0.66%
67~88
245
0.38%
89~110
143
0.22%
111~133
103
0.16%
134~160
49
0.08%
161~186
40
0.06%
187~233
29
0.05%
238~1064
17
0.03%
num_homolog_complex_compound
Bin▲
Count
Percentage
0
10773
53.41%
1~35
6605
32.75%
36~70
1292
6.41%
71~105
310
1.54%
106~140
317
1.57%
141~177
165
0.82%
178~212
142
0.70%
213~248
149
0.74%
249~284
244
1.21%
285~323
130
0.64%
324~407
42
0.21%
Null
44171
-
num_homolog_complex_metal
Bin▲
Count
Percentage
0
8910
44.18%
1~14
5365
26.60%
15~28
2058
10.20%
29~42
1406
6.97%
43~56
1437
7.12%
57~70
468
2.32%
71~84
308
1.53%
85~98
124
0.61%
99~112
65
0.32%
113~147
20
0.10%
148~152
8
0.04%
Null
44171
-
num_homolog_complex_nucleotide
Bin▲
Count
Percentage
0
16825
83.42%
1~14
1694
8.40%
15~28
352
1.75%
29~42
171
0.85%
43~56
729
3.61%
57~70
232
1.15%
71~84
73
0.36%
85~108
31
0.15%
109~137
26
0.13%
139~206
31
0.15%
225~294
5
0.02%
Null
44171
-
num_homolog_complex_otherpoly
Bin▲
Count
Percentage
0
16982
84.20%
1~11
2465
12.22%
12~22
382
1.89%
23~33
126
0.62%
34~44
58
0.29%
45~55
52
0.26%
57~69
40
0.20%
72~85
24
0.12%
86~101
22
0.11%
102~115
16
0.08%
117~119
2
0.01%
Null
44171
-
num_homolog_complex_precipitant
Bin▲
Count
Percentage
0
8666
42.97%
1~22
6083
30.16%
23~44
1647
8.17%
45~66
1128
5.59%
67~88
795
3.94%
89~110
632
3.13%
111~132
481
2.38%
133~154
436
2.16%
155~176
195
0.97%
177~203
81
0.40%
204~258
25
0.12%
Null
44171
-
num_monomer
Bin▲
Count
Percentage
0
6035
29.92%
1~3
11751
58.26%
4~6
1983
9.83%
7~9
310
1.54%
10~12
56
0.28%
13~15
20
0.10%
16~18
10
0.05%
19~21
4
0.02%
Null
44171
-
num_homomer
Bin▲
Count
Percentage
0
8861
43.93%
1~19
8094
40.13%
20~38
1907
9.46%
39~57
862
4.27%
58~76
200
0.99%
77~95
112
0.56%
96~137
35
0.17%
140~166
29
0.14%
167~220
26
0.13%
221~250
29
0.14%
252~290
14
0.07%
Null
44171
-
num_heteromer
Bin▲
Count
Percentage
0
9460
46.90%
1~28
7798
38.66%
29~56
1388
6.88%
57~84
591
2.93%
85~112
286
1.42%
113~140
214
1.06%
141~168
161
0.80%
170~243
56
0.28%
245~275
77
0.38%
276~304
115
0.57%
305~373
23
0.11%
Null
44171
-
div_hum
Bin▲
Count
Percentage
0
1242
1.93%
1
63098
98.07%
div_pri
Bin▲
Count
Percentage
0
3451
5.36%
1
1164
1.81%
2
2720
4.23%
3
57005
88.60%
div_rod
Bin▲
Count
Percentage
0
5768
8.96%
1
1986
3.09%
2
56586
87.95%
div_mam
Bin▲
Count
Percentage
0
6967
10.83%
1
4256
6.61%
2
9371
14.56%
3
43746
67.99%
div_vrt
Bin▲
Count
Percentage
0
9741
15.14%
1
2210
3.43%
2
3106
4.83%
3
3303
5.13%
4
8850
13.76%
5
37130
57.71%
div_inv
Bin▲
Count
Percentage
0
21099
32.79%
1~2
5697
8.85%
3~4
6075
9.44%
5~6
10085
15.67%
7~8
9661
15.02%
9~10
6382
9.92%
11~12
5341
8.30%
div_pln
Bin▲
Count
Percentage
0
33361
51.85%
1~3
7827
12.17%
4~6
3218
5.00%
7~9
2686
4.17%
10~12
2399
3.73%
13~15
2244
3.49%
16~18
3245
5.04%
19~21
4754
7.39%
22
4606
7.16%
div_bct
Bin▲
Count
Percentage
0
53179
82.65%
1~10
4938
7.67%
11~20
1480
2.30%
21~30
948
1.47%
31~40
594
0.92%
41~50
621
0.97%
51~60
687
1.07%
61~70
451
0.70%
71~80
313
0.49%
81~90
531
0.83%
91~98
598
0.93%
div_arc
Bin▲
Count
Percentage
0
57533
89.42%
1~3
3539
5.50%
4~6
757
1.18%
7~9
705
1.10%
10~12
406
0.63%
13~15
433
0.67%
16~18
356
0.55%
19~20
611
0.95%
num_splice_variants
Bin▲
Count
Percentage
1~3
61775
96.01%
4~6
2101
3.27%
7~9
340
0.53%
10~12
75
0.12%
13~15
23
0.04%
16~18
14
0.02%
19~21
3
0.00%
23~26
5
0.01%
29~35
3
0.00%
37
1
0.00%
num_variant_sites
Bin▲
Count
Percentage
0
51746
80.43%
1~14
11831
18.39%
15~28
426
0.66%
29~42
135
0.21%
43~56
58
0.09%
57~70
42
0.07%
71~86
27
0.04%
87~108
23
0.04%
111~141
21
0.03%
146~200
20
0.03%
203~1363
11
0.02%
num_variants
Bin▲
Count
Percentage
0
54030
83.98%
1~3
7819
12.15%
4~6
1828
2.84%
7~9
446
0.69%
10~12
139
0.22%
13~15
43
0.07%
16~18
22
0.03%
19~22
7
0.01%
23~25
5
0.01%
28
1
0.00%
Bin▲
Count
Percentage
num_pubmed
Bin▲
Count
Percentage
0
1237
1.92%
1~10
57776
89.80%
11~20
3977
6.18%
21~30
812
1.26%
31~40
298
0.46%
41~50
104
0.16%
51~60
58
0.09%
61~70
38
0.06%
72~86
21
0.03%
87~124
15
0.02%
126~193
4
0.01%